Metroid Prime. I hope Metroid Prime 3 is truely the last one. There's only so much of Dark Samus and Phazon that I can stomach.
Anything Megaman thats not the original, X, or Legends. Zero, .exe, and all those other megaman series I never even touched. Capcom has an extremely bad habit not finishing the storyline of one Megaman before jumping to another. Legends, The original, and X are still unfinished, and probably will remain unfinished forever.
Dynasty Warriors. Every game that comes out, they promise it's the last one.
Pokemon. The original was fun. Gold and Silver were ok. After that, it was nothing new. Just expansion pack after expansion pack, yet more people buy it and think it's something "brand new and original." Either change Pokemon entirely to make it into a full fledged story-driven RPG, or drop it. The "catch monsters and battle with them to win badges" thing has been overdone. How about a Pokemon game where not only the monsters fight, but the trainers as well? And you have a party of 3 trainers as well as their monsters gathering to stop something? You know, like a JRPG type of thing? That would be a better change for Pokemon and might actually make it more fun.
And last but not least......MARIO PARTY/SPORTS GAMES!!!!!!! The time they put into Mario Party or Mario Sports games could be put into making Mario adventure games. We see a solid and fun Mario adventure maybe once or twice per generation, yet we see an overflow of Mario Party and/or sports games. Where's "Mario and Luigi Wii?" Where's "Super Mario RPG 2?" Where's "Super Mario 128?" Yes I know that 128 was replaced by Sunshine and Mario Galaxy is coming, but these are just too few and far between. Mario needs more action and less....sports. Stick to Mario Kart and leave the rest alone.