Whatever you do make sure you dont watch the dubbed amreican version. if you are gonna watch trigun, watch the original japanese ones with english subtitles. The dubed voices are rediculous, i dont think that they could have made them any worse if they tried. The japanese voices are perfect, they suit their resepective charachters perfectly. Aside from the the dubbed vegetas voice in DBZ, the original vash voices is probably the best voice to suit a character ive ever heared.
As far as dubs go, trigun wasn't bad at all. Up there with the Cowboy bebop dub. Granted, I prefer subs, but I did geta kick out of their voices Especially wolfwood's That and I think the guy who did Vash's dub voice also did Kaneda's voice in the new Akira dub. But then again, I like seeing how VA's get around. American or otherwise. You should see how Seki Tomokazu gets around VA wise