My theory is that Madara will get defeated by Sakura.
After which, Tsunade dies and Sakura is left to be the Hokage
And Karin will be the final villain and will have to battle it out with our dear Hokage.
It all makes sense now.
All jokes aside, this chapter was great, Sas and Naru will likely not die on us, but it is still intriguing to see how this pans out.